Analgesic Effect of Preoperative Intravenous Administration of Paracetamol on Post-cesarean Pain: A Randomized Clinical Trial

Background: Pain control after every surgery, especially cesarean section, is very important, and physicians strive to discover pain methods using the least amount of opioids. Paracetamol a non-opioid analgesic with few complications. Objectives: The present study aimed investigate effect preoperative intravenous administration paracetamol on post-cesarean pain. Methods: This randomized, double-blind clinical trial was conducted 240 pregnant women under spinal anesthesia who were candidates for elective section. patients’ weight, height, age, body mass index (BMI) recorded, patients randomly divided into 2 equal groups (n = 120). In first group, 10 mg/kg in 100 mL normal saline (paracetamol group) and, second (control administered 15 minutes before surgery intravenously. Blood pressure, pulse rate, chills, nausea recorded during 1 hour surgery; addition, visual analogue scale (VAS) need additional analgesics 1, 2, 4, 6, 12, 24 hours surgery. Results: Mean scores significantly lower group (4.01 ± 2.22) than 6 (4.83 2.35; P 0.008) (2.26 1.85 2.67 1.80, respectably; 0.038) meperidine consumption but it not significant. No significant difference found between frequency chills (P > 0.05). Conclusions: Within limitations current study, reduced within hours.